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Attribution: NIH Image Gallery from Bethesda, Maryland, USA, Public domain, via Wikimedia Commons
A novel mechanism to explain the different unrelated symptoms of COVID-19 has come to light by exploiting the second fastest Supercomputer in the world known as Summit supercomputer at Oak Ridge National Lab in Tennessee. The study involved analysing 2.5...
Development of vaccine for COVID-19 is a global priority. In this article, the author has reviewed and evaluated research and development and the present status of vaccine development. COVID-19 disease, caused by SARS-CoV-2 virus, has been steadily increasing in the...
NeoCoV, a coronavirus strain related to MERS-CoV found in bats (NeoCoV is not a new variant of SARS-CoV-2, the human coronavirus strain responsible for COVID-19 pandemic) has been reported to be the first case of a MERS-CoV variant using ACE2....
Spikevax Bivalent Original/Omicron Booster Vaccine, the first bivalent COVID-19 booster vaccine developed by Moderna has received MHRA approval. Unlike the Spikevax Original, the bivalent version targets both the original coronavirus variants from 2020 and the Omicron variant as well as...
JN.1 sub-variant whose earliest documented sample was reported on 25 August 2023 and which was later reported by the researchers to have higher transmissibility and immune escape ability, has now been designated a variant of interest (VOIs) by WHO. In the last few...
WHO’s Technical Advisory Group on SARS-CoV-2 Virus Evolution (TAG-VE) was convened on 26th November 2021 to assess the variant B.1.1.529. Based on the available evidences, the group of experts has advised WHO that this variant should be designated as a Variant...
A number of ingredients have been used as carriers to successfully deliver vaccines and to enhance their immune response. These include peptides, liposomes, lipid nanoparticles and polymers to name a few. Recently, Lam et al describe the use of...
Existing biologics such as Canakinumab (monoclonal antibody), Anakinra (monoclonal antibody) and Rilonacept (fusion protein) can be exploited as therapeutics that restrain inflammation in COVID-19 patients. In addition, designer monoclonal antibodies can provide passive immunity by neutralizing the SARS-CoV-2 virus...
To protect the NHS and save lives., National Lockdown has been put in place across the UK. People have been asked to stay home at home. This is in view of recent rapid increase in number of cases across...
In order to raise levels of protection across the population against the Omicron variant, the Joint Committee on Vaccination and Immunisation (JCVI)1 of UK has recommended that the booster programme should be expanded to include all remaining adults aged 18...
With the advent of COVID-19, there seems to be a negative selection pressure working against those who may be genetically or otherwise (due to their lifestyle, co-morbidities etc.) predisposed to develop severe symptoms, ultimately leading to death. Majority of...
A recent study suggests increased risk of formation of coronavirus hotspots caused due to deforestation and livestock revolution leading to zoonotic transmission of coronavirus from bats to humans. The study seems to sow enough subliminal seeds in the minds...
The containment scheme based on 'quarantine' or 'social distancing' has emerged as the main tool in fight against COVID-19. But, there are concerns about economic and psychological costs. A researcher offers ''social containment'' as an alternative which seems to...
In the practice of medicine, one generally prefers time tested proven path while treating and trying to prevent diseases. An innovation is usually expected to pass the test of time. The three approved COVID-19 vaccines, two mRNA vaccines and...
A biotech firm, Moderna, Inc. has announced that ‘mRNA-1273’, their mRNA vaccine against novel coronavirus has shown positive results in the phase 1 clinical trials In the race for the development of vaccines for the treatment of COVID-19, Moderna Inc.,...
MicroRNAs or in short miRNAs (not to be confused with mRNA or messenger RNA) were discovered in 1993 and have been extensively studied in the past two decades or so for their role in regulating gene expression. miRNAs are...
The assay time is considerably reduced from about an hour to few minutes by the newly reported RTF-EXPAR method which uses reverse transcriptase-free (RTF) approach for conversion of RNA into DNA followed by EXPAR (Exponential Amplification Reaction) for amplification at...
Medicines and Healthcare products Regulatory Agency (MHRA), the regulator of all medicines and medical devices in the UK has approved Moderna’s COVID-19 vaccine after meeting the required safety, quality and effectiveness standards for use in the UK (1).   This is the...
The B.1.617 variant that has caused the recent COVID-19 crisis in India has been implicated in increased transmission of the disease among the population and poses a significant challenge with respect to disease severity and effectiveness of currently available...
The B.1.1.529 variant was first reported to WHO from South Africa on 24th November 2021. The first known confirmed B.1.1.529 infection was from a specimen collected on 9th November 20211. Another source2 indicates that this variant was first detected in samples collected on...
All approved COVID-19 vaccines so far are administered in the form of injections. What if the vaccines could be conveniently delivered as spray in the nose? If you do not like shots, here may be the good news! Intranasal administration of...
Europe is reeling with an unusually high number of COVID 19 cases for the past few weeks and this can be attributed to the highly transmissible delta variant along with relaxation in COVID norms with respect to wearing of...
University College London Hospitals (UCLH) has announced neutralising antibody trial against COVID-19. The announcement on 25 December 2020 says ‘’UCLH doses first patient in the world in Covid-19 antibody trial’’ and ‘’ Researchers in the STORM CHASER study led by...
Sotrovimab, a monoclonal antibody already approved for mild to moderate COVID-19 in several countries gets approval by MHRA in the UK. This antibody was intelligently designed with a mutating virus in mind. A highly conserved region of the spike protein was...
COVID-19 situation across Europe and central Asia is very serious. According to WHO, Europe could face over 2 million COVID-19 deaths by March 2022. Wearing masks, physical distancing and vaccination are key preventive actions that could help avoid reaching this...

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