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Advanced age and comorbidities are known to be high risk factors for COVID-19. Does genetic make-up predispose some people making them more susceptible to severe symptoms? Conversely, does genetic make-up enable some people to have innate immunity making them...
There are reports of Russia registering world’s first vaccine against novel corona virus while the phase 3 trial of this vaccine is still in progress. Developed jointly by the Gamaleya Research Institute and the Russian Defence Ministry, this vaccine is based on the use...
The causative analysis of the current crisis in India caused by COVID-19 can be attributed to various factors sedentary lifestyle of the population, complacency setting in due to the perception of pandemic being over, predisposition of Indian population to...
Molnupiravir, a nucleoside analog of cytidine, a drug that has shown excellent oral bioavailability and promising results in Phase 1 and Phase 2 trials, could prove to be a magic bullet acting as an anti-viral agent against SARS-CoV2 in humans. Major...
Interim data from the phase III clinical trial of Oxford University/AstraZeneca COVID-19 Vaccine show the vaccine is effective at preventing COVID-19 caused due to SARS-CoV-2 virus and offers a high level of protection against the disease.  The phase III trial tested two...
The preliminary report of findings from the clinical trial NCT02735707 reported in preprint suggests that Tocilizumab and Sarilumab, the interleukin-6 receptor antagonists are effective in treating critically ill COVID-19 patients and improve survival. Severely ill COVID-19 patients receiving intensive care support responded well to...
Researchers at Southern Illinois University have reported a new variant of SARS COV-2 Virus in the USA.   According to reports published on preprint server which is yet to be peer-reviewed, researchers have identified a new variant using genomic virus surveillance approach.   Referred as 20C-US, this variant...
The B.1.617 variant that has caused the recent COVID-19 crisis in India has been implicated in increased transmission of the disease among the population and poses a significant challenge with respect to disease severity and effectiveness of currently available...
Controlling the rate of COVID-19 spread requires an accurate and a faster virus testing strategy. RT-PCR (reverse transcriptase polymerase chain reaction), the most accurate testing method being currently employed is a two-step test that takes around 60 minutes per sample.   The researchers from...
A type of virus that preys on bacteria could be harnessed to combat bacterial infections in patients whose immune systems have been weakened by the SARS-CoV-2 virus that causes the COVID-19 disease, according to an expert at the University...
A novel mechanism to explain the different unrelated symptoms of COVID-19 has come to light by exploiting the second fastest Supercomputer in the world known as Summit supercomputer at Oak Ridge National Lab in Tennessee. The study involved analysing 2.5...
Development of vaccine for COVID-19 is a global priority. In this article, the author has reviewed and evaluated research and development and the present status of vaccine development. COVID-19 disease, caused by SARS-CoV-2 virus, has been steadily increasing in the...
In countries like UK, USA and Italy which are badly hit by the COVID-19 pandemic, the life expectancy has reduced by at least 1.2-1.3 years. Diseases and risk factors lead to premature deaths and disabilities and result in ‘burden’ on the...
Povidone Iodine (PVP-I) can be used in the form of mouthwash and nasal spray (especially in Dental and ENT settings) to prevent the spread of the SARS-CoV-2 virus, to reduce cross-infection and to manage patients at the early stage of disease.   Povidone...
A number of ingredients have been used as carriers to successfully deliver vaccines and to enhance their immune response. These include peptides, liposomes, lipid nanoparticles and polymers to name a few. Recently, Lam et al describe the use of...
Clinical Trials to evaluate effectiveness of anti-malarial drug, hydroxychloroquine (HCQ) and antibiotic, Azithromycin in treating older people with COVID-19 begins in the UK and USA with an aim to reducing the severity of symptoms and avoiding hospitalization Of late, there...
2-Deoxy-D-Glucose(2-DG), a glucose analog that inhibits glycolysis, has recently received Emergency Use Authorization (EUA) in India for the treatment of moderate to severe COVID-19 patients. The molecule has been extensively researched and used in clinical trials for its ant-cancer properties....
What causes severe COVID-19 symptoms? Evidences suggest inborn errors of type I Interferon immunity and autoantibodies against type I Interferon are causal for critical COVID-19. These errors can be identified using whole genome sequencing, thereby leading to proper quarantine...
MicroRNAs or in short miRNAs (not to be confused with mRNA or messenger RNA) were discovered in 1993 and have been extensively studied in the past two decades or so for their role in regulating gene expression. miRNAs are...
WHO doesn't recommend face masks generally to the healthy people. However, CDC has now laid down new guideline and say ''people should wear cloth masks when they go outside''. New evidence suggest that the usage of surgical face masks...
Several studies indicate that activation of NLRP3 inflammasome is responsible for acute respiratory distress syndrome and/or acute lung injury (ARDS/ALI) seen in severely ill COVID-19 patients which often result in death due to multiple organ failure. This suggests NLRP3...
A plasmid DNA vaccine against SARS-CoV-2 has been found to induce immunity in animal trials. Few other DNA based vaccine candidates are at early stages of clinical trials. Interestingly, plasmid DNA vaccines can be developed in a short period of time....
There is no clarity on the natural origin of SARS CoV-2 as no intermediate host has been found yet that transmits it from bats to humans. On the other hand, there are circumstantial evidences to suggest a laboratory origin...
The plant derived agent, Thapsigargin (TG) has been used in traditional medicine for long time. TG has shown promises as a potential anti-cancer drug because of its biological property to inhibit the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) pump which is necessary for...
A recent study suggests increased risk of formation of coronavirus hotspots caused due to deforestation and livestock revolution leading to zoonotic transmission of coronavirus from bats to humans. The study seems to sow enough subliminal seeds in the minds...

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