Findings from recently concluded phase 2 clinical trials in Canada and the UK suggest nitric oxide (NO) could be very helpful in preventing and treating COVID-19. Nitric oxide...
MHRA, UK regulator has issued an advisory against the use of AstraZeneca vaccine as it has been shown to induce the formation of blood clots along with thrombocytopenia in rare cases (4 events in a million). However,...
All approved COVID-19 vaccines so far are administered in the form of injections. What if the vaccines could be conveniently delivered as spray in the nose? If you do not like shots, here may be the good news! Intranasal...
Routine sero-surveillance of the population to estimate presence of antibodies to COVID-19 is required to understand the development of herd immunity in a population. Data from the sero-surveillance study of population in the Ischgl town of Austria throws light on...
MicroRNAs or in short miRNAs (not to be confused with mRNA or messenger RNA) were discovered in 1993 and have been extensively studied in the past two decades or so for their role in regulating gene expression....
Results from the phase2 trial support the view that subcutaneous administration of IFN- β for treatment of COVID-19 enhances speed of recovery and reduces mortality. The extraordinary situation presented...
In countries like UK, USA and Italy which are badly hit by the COVID-19 pandemic, the life expectancy has reduced by at least 1.2-1.3 years. Diseases and risk factors lead...
Advanced age and comorbidities are known to be high risk factors for COVID-19. Does genetic make-up predispose some people making them more susceptible to severe symptoms? Conversely, does genetic make-up enable some people to have innate immunity...
The plant derived agent, Thapsigargin (TG) has been used in traditional medicine for long time. TG has shown promises as a potential anti-cancer drug because of its biological property to inhibit the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) pump which is...
Povidone Iodine (PVP-I) can be used in the form of mouthwash and nasal spray (especially in Dental and ENT settings) to prevent the spread of the SARS-CoV-2 virus, to reduce cross-infection and to manage patients at the early stage...
A number of ingredients have been used as carriers to successfully deliver vaccines and to enhance their immune response. These include peptides, liposomes, lipid nanoparticles and polymers to name a few. Recently, Lam et al describe...
COVID-19 pandemic has caused a major economic impact all over the globe and has resulted in disruption of “normal” life. Countries across the world are battling to find solutions to this disease that includes strengthening the immune...
In the practice of medicine, one generally prefers time tested proven path while treating and trying to prevent diseases. An innovation is usually expected to pass the test of time. The three approved COVID-19 vaccines, two mRNA...
A plasmid DNA vaccine against SARS-CoV-2 has been found to induce immunity in animal trials. Few other DNA based vaccine candidates are at early stages of clinical trials. Interestingly, plasmid DNA vaccines can be developed in a short...
Researchers at Southern Illinois University have reported a new variant of SARS COV-2 Virus in the USA.   According to reports published on preprint server which is yet to be peer-reviewed, researchers have identified a new variant using genomic...
Medicines and Healthcare products Regulatory Agency (MHRA), the regulator of all medicines and medical devices in the UK has approved Moderna’s COVID-19 vaccine after meeting the required safety, quality and effectiveness standards for use in the UK (1).  
The preliminary report of findings from the clinical trial NCT02735707 reported in preprint suggests that Tocilizumab and Sarilumab, the interleukin-6 receptor antagonists are effective in treating critically ill COVID-19 patients and improve survival.
Controlling the rate of COVID-19 spread requires an accurate and a faster virus testing strategy. RT-PCR (reverse transcriptase polymerase chain reaction), the most accurate testing method being currently employed is a two-step test that takes around 60 minutes per sample.  
To protect the NHS and save lives., National Lockdown has been put in place across the UK. People have been asked to stay home at home. This is in view of recent rapid increase in number of...
Interim data from the phase III clinical trial of Oxford University/AstraZeneca COVID-19 Vaccine show the vaccine is effective at preventing COVID-19 caused due to SARS-CoV-2 virus and offers a high level of protection against the disease. 
Viral proteins are administered as antigen in the form of a vaccine and the immune system of the body forms antibodies against the given antigen thus providing protection against any future infection. Interestingly, this is first time in...
What causes severe COVID-19 symptoms? Evidences suggest inborn errors of type I Interferon immunity and autoantibodies against type I Interferon are causal for critical COVID-19. These errors can be identified using whole genome sequencing, thereby leading to...
Anti-viral properties of manuka honey are due to the presence of methylglyoxal (MG), an arginine directed glycating agent that modifies sites specifically present in the SARS-CoV-2 genome, thereby interfering with its replication and inhibiting the virus. In...
University College London Hospitals (UCLH) has announced neutralising antibody trial against COVID-19. The announcement on 25 December 2020 says ‘’UCLH doses first patient in the world in Covid-19 antibody trial’’ and ‘’ Researchers in the STORM CHASER study...
Several new strains of the virus have emerged since the pandemic began. New variants were reported as early as February 2020. The current variant that has brought the UK to standstill this Christmas is said to be...

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