A new vaccine, R21/Matrix-M has been recommended by the WHO for the prevention of malaria in children.
Earlier in 2021, WHO had recommended RTS,S/AS01 malaria vaccine for prevention of malaria in children. This was the first malaria vaccine to...
This year’s Nobel Prize in Physiology or Medicine 2023 has been awarded jointly to Katalin Karikó and Drew Weissman "for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19".
Both Katalin Karikó and...
Brain-eating Amoeba (Naegleria fowleri) is responsible for brain infection known as primary amoebic meningoencephalitis (PAM). The infection rate is very low but highly fatal. The infection is contacted through taking up water contaminated with N. fowleri through nose. Antibiotics...
Researchers have found that memory in aged monkey improved following a single administration of low-dose Klotho protein. It is the first time that restoring levels of klotho has been shown to improve cognition in a non-human primate. This paves the...
In a recent in-vivo study on Zebrafish, researchers successfully induced disc regeneration in a degenerated disc by activating an endogenous Ccn2a-FGFR1-SHH signalling cascade. This suggests that Ccn2a protein could be exploited in promotion of IVD regeneration for treatment of backpain.
Back...
Using appropriate enzymes, researchers removed ABO blood group antigens from donor kidney and lung ex-vivo, to overcome ABO blood group mismatch. This approach can solve organ shortage by improving availability of donor organs for transplantation considerably and make the...
On 08 August 2022, the expert group of WHO arrived at consensus on nomenclature of known and new monkeypox virus (MPXV) variants or clades. Accordingly, the former Congo Basin (Central African) clade will be known as Clade one(I) and...
Two henipaviruses, Hendra virus (HeV) and the Nipah virus (NiV) are already known to cause fatal disease in humans. Now, a novel henipavirus has been identified in febrile patients in Eastern China. This is phylogenetically distinct strain of henipavirus...
Monkeypox virus (MPXV) is closely related to smallpox, the deadliest virus in history responsible for unparalleled devastation of human population in the past centuries accounting for more deaths than any other single infectious disease, even plague and cholera. With...
Successful development of mRNA vaccines, BNT162b2 (of Pfizer/BioNTech) and mRNA-1273 (of Moderna) against the novel coronavirus SARS CoV-2 and the important role these vaccines played recently in mass immunisation of people against COVID-19 pandemic in several countries has established...
RNA technology has proved its worth recently in development of mRNA vaccines BNT162b2 (of Pfizer/BioNTech) and mRNA-1273 (of Moderna) against COVID-19. Based on degrading the coding RNA in animal model, French scientists have reported a potent strategy and proof of...
Doctors and scientists of University of Maryland School of Medicine have successfully transplanted heart of a genetically engineered pig (GEP) into an adult patient with end-stage heart disease. This surgery was patient’s only option left for survival after being...
Self-assembled nanostructures formed using supramolecular polymers containing peptide amphiphiles (PAs) containing bio active sequences have shown great results in mouse model of SCI and holds immense promise, in humans, for an effective treatment of this debilitating condition that severely impacts the quality of life...
Development of multi-drug resistance (MDR) bacteria in the past five decades have led to increasing research in search of a drug candidate to address this AMR issue. A fully synthetic broad-spectrum antibiotic, Iboxamycin, provides hope to treat both Gram-positive and Gram-negative bacteria...
Developing vaccine against malaria has been among the biggest challenges before science. MosquirixTM , a vaccine against malaria has recently been approved by WHO. Although the efficacy of this vaccine is about 37%, yet this is great step forward as this...
Donepezil is an acetylcholinesterase inhibitor1. Acetylcholinesterase breaks down the neurotransmitter acetylcholine2, thereby reducing acetylcholine signalling in the brain. Acetylcholine (ACh) enhances the encoding of new memories and therefore improves learning3. Donepezil improves cognitive performance in mild cognitive impairment (MCI)...
Selegiline is an irreversible monoamine oxidase (MAO) B inhibitor1. Monoamine neurotransmitters, such as serotonin, dopamine and norepinephrine, are derivatives of amino acids2. The enzyme monoamine oxidase A (MAO A) primarily oxidises (breaks down) serotonin and norepinephrine in the brain,...
Fibrotic diseases are known to affect several vital organs in the body and are a major cause of mortality and morbidity. There has been a little success in treatment of these diseases so far. ILB®, the Low Molecular Weight...
Viral proteins are administered as antigen in the form of a vaccine and the immune system of the body forms antibodies against the given antigen thus providing protection against any future infection. Interestingly, this is first time in human history...
In June 2020, RECOVERY trial from a group of researchers in Oxford University UK reported use of low-cost dexamethasone1 for treatment of severely ill COVID-19 patients by reducing inflammation. Recently, a protein-based drug, called Aviptadil, has been fast tracked by FDA...
Tildrakizumab is being marketed by Sun Pharma under the trade name Ilumya, and has been approved by FDA in March 2018 after analysis of data from Phase III multi-centre, randomised, placebo-controlled clinical trials reSURFACE 1 and reSURFACE 2. Both...
Sun Pharma has presented data on ODOMZO® (drug for treatment of skin cancer) and LEVULAN® KERASTICK® + BLU-U®, (for treating precancerous lesions) supporting safety and efficacy.
ODOMZO®
ODOMZO® (Sonidegib) was approved by FDA in July 2015. This was acquired by Sun...
In a breakthrough research, the scientists have demonstrated that aminoglycosides (gentamicin) antibiotic could be used to treat familial dementia
The antibiotics gentamicin, neomycin, streptomycin etc are commonly used to treat bacterial infections. These are broad spectrum antibiotics belonging to aminoglycosides...
The effects of partial gravity (example on Mars) on our muscular system is still partly understood. Study in rats shows that resveratrol, a compound found in grape skin and red wine, can mitigate muscle impairment in a Mars partial...
Early nerve transfer surgery to treat paralysis of arms and hands due to spinal injury is helpful in improving function. Post two years of surgery and physiotherapy, patients regained function in elbows and hands leading to improvement in independence...
