Fibrotic diseases are known to affect several vital organs in the body and are a major cause of mortality and morbidity. There has been a little success in treatment of these diseases so far. ILB®, the Low...
Viral proteins are administered as antigen in the form of a vaccine and the immune system of the body forms antibodies against the given antigen thus providing protection against any future infection. Interestingly, this is first time in...
What causes severe COVID-19 symptoms? Evidences suggest inborn errors of type I Interferon immunity and autoantibodies against type I Interferon are causal for critical COVID-19. These errors can be identified using whole genome sequencing, thereby leading to...
University College London Hospitals (UCLH) has announced neutralising antibody trial against COVID-19. The announcement on 25 December 2020 says ‘’UCLH doses first patient in the world in Covid-19 antibody trial’’ and ‘’ Researchers in the STORM CHASER study...
Several new strains of the virus have emerged since the pandemic began. New variants were reported as early as February 2020. The current variant that has brought the UK to standstill this Christmas is said to be...
In June 2020, RECOVERY trial from a group of researchers in Oxford University UK reported use of low-cost dexamethasone1 for treatment of severely ill COVID-19 patients by reducing inflammation. Recently, a protein-based drug, called Aviptadil, has been fast tracked...
Existing biologics such as Canakinumab (monoclonal antibody), Anakinra (monoclonal antibody) and Rilonacept (fusion protein) can be exploited as therapeutics that restrain inflammation in COVID-19 patients. In addition, designer monoclonal antibodies can provide passive immunity by neutralizing the...
There are reports of Russia registering world’s first vaccine against novel corona virus while the phase 3 trial of this vaccine is still in progress. Developed jointly by the Gamaleya Research Institute and the Russian Defence Ministry, this vaccine is based on...
Low-cost dexamethasone reduces death by up to one third in hospitalised patients with severe respiratory complications of COVID-19 The scientists have been sceptic over the rationale for prolonged corticosteroid...
Easily correctable condition of Vitamin D Insufficiency (VDI) has very severe implications for COVID-19. In countries worst affected by COVID-19 such as Italy, Spain and Greece, Vitamin D insufficiency (VDI) rates were high in the range of...
Clinical Trials to evaluate effectiveness of anti-malarial drug, hydroxychloroquine (HCQ) and antibiotic, Azithromycin in treating older people with COVID-19 begins in the UK and USA with an aim to reducing the severity of symptoms and avoiding hospitalization
Several studies indicate that activation of NLRP3 inflammasome is responsible for acute respiratory distress syndrome and/or acute lung injury (ARDS/ALI) seen in severely ill COVID-19 patients which often result in death due to multiple organ failure. This...
A combination of biological and computational approach to study protein-protein interactions (PPIs) between the viral and the host proteins in order to identify and repurpose drugs for an effective treatment of COVID-19 and possibly other infections as...
Development of vaccine for COVID-19 is a global priority. In this article, the author has reviewed and evaluated research and development and the present status of vaccine development. COVID-19...
Laboratory tests for diagnosis of COVID-19 currently in practice as advised by the international bodies of experts are reviewed and evaluated. The COVID-19 disease, that originated in Wuhan China,...
In a breakthrough research, the scientists have demonstrated that aminoglycosides (gentamicin) antibiotic could be used to treat familial dementia The antibiotics gentamicin, neomycin, streptomycin etc are commonly used to...
The effects of partial gravity (example on Mars) on our muscular system is still partly understood. Study in rats shows that resveratrol, a compound found in grape skin and red wine, can mitigate muscle impairment in a...
Early nerve transfer surgery to treat paralysis of arms and hands due to spinal injury is helpful in improving function. Post two years of surgery and physiotherapy, patients regained function in elbows and hands leading to improvement...
Experiments in mice show that injecting amino-bridged nucleic acid-modified antisense oligonucleotides (amNA-ASO) into the brain is a potent and efficient approach to target SNCA protein for treatment of Parkinson’s disease
Animal study describes role of URI protein in tissue regeneration after exposure to high-dose radiation from radiation therapy Radiation Therapy or Radiotherapy is an effective technique for killing cancer...
Study in mice and human cells describes reactivation of an important tumour suppressive gene using a vegetable extract thus offering a promising strategy for cancer treatment Cancer is the...
For the first time, delivery of genetic material induced heart cells to de-differentiate and proliferate in a large-animal model after myocardial infarction. This led to improvement in heart functions.
Study describes a novel mechanism involved in progression of non-alcoholic fatty liver disease and highlights protein Mitofusin 2 as having the potential to be a possible treatment model Non-alcoholic...
Study shows a new combination therapy of two plant-derived compounds to reverse cognitive impairment in mice At least 50 million people are living with Alzheimer’s disease worldwide. The total...
New study shows a second case of successful HIV remission after a bone marrow transplant At least one million people die due to HIV-related causes every year and almost...

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