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Donepezil is an acetylcholinesterase inhibitor1. Acetylcholinesterase breaks down the neurotransmitter acetylcholine2, thereby reducing acetylcholine signalling in the brain. Acetylcholine (ACh) enhances the encoding of new memories and therefore improves learning3. Donepezil improves cognitive performance in mild cognitive impairment (MCI)...
Selegiline is an irreversible monoamine oxidase (MAO) B inhibitor1. Monoamine neurotransmitters, such as serotonin, dopamine and norepinephrine, are derivatives of amino acids2. The enzyme monoamine oxidase A (MAO A) primarily oxidises (breaks down) serotonin and norepinephrine in the brain,...
Molnupiravir, a nucleoside analog of cytidine, a drug that has shown excellent oral bioavailability and promising results in Phase 1 and Phase 2 trials, could prove to be a magic bullet acting as an anti-viral agent against SARS-CoV2 in humans. Major...
Fibrotic diseases are known to affect several vital organs in the body and are a major cause of mortality and morbidity. There has been a little success in treatment of these diseases so far. ILB®, the Low Molecular Weight...
Viral proteins are administered as antigen in the form of a vaccine and the immune system of the body forms antibodies against the given antigen thus providing protection against any future infection. Interestingly, this is first time in human history...
What causes severe COVID-19 symptoms? Evidences suggest inborn errors of type I Interferon immunity and autoantibodies against type I Interferon are causal for critical COVID-19. These errors can be identified using whole genome sequencing, thereby leading to proper quarantine...
University College London Hospitals (UCLH) has announced neutralising antibody trial against COVID-19. The announcement on 25 December 2020 says ‘’UCLH doses first patient in the world in Covid-19 antibody trial’’ and ‘’ Researchers in the STORM CHASER study led by...
Several new strains of the virus have emerged since the pandemic began. New variants were reported as early as February 2020. The current variant that has brought the UK to standstill this Christmas is said to be 70% more...
In June 2020, RECOVERY trial from a group of researchers in Oxford University UK reported use of low-cost dexamethasone1 for treatment of severely ill COVID-19 patients by reducing inflammation. Recently, a protein-based drug, called Aviptadil, has been fast tracked by FDA...
Existing biologics such as Canakinumab (monoclonal antibody), Anakinra (monoclonal antibody) and Rilonacept (fusion protein) can be exploited as therapeutics that restrain inflammation in COVID-19 patients. In addition, designer monoclonal antibodies can provide passive immunity by neutralizing the SARS-CoV-2 virus...
There are reports of Russia registering world’s first vaccine against novel corona virus while the phase 3 trial of this vaccine is still in progress. Developed jointly by the Gamaleya Research Institute and the Russian Defence Ministry, this vaccine is based on the use...
Low-cost dexamethasone reduces death by up to one third in hospitalised patients with severe respiratory complications of COVID-19 The scientists have been sceptic over the rationale for prolonged corticosteroid treatment in the Acute Respiratory Distress Syndrome (ARDS) caused by COVID-19....
Easily correctable condition of Vitamin D Insufficiency (VDI) has very severe implications for COVID-19. In countries worst affected by COVID-19 such as Italy, Spain and Greece, Vitamin D insufficiency (VDI) rates were high in the range of 70-90%.; on...
Clinical Trials to evaluate effectiveness of anti-malarial drug, hydroxychloroquine (HCQ) and antibiotic, Azithromycin in treating older people with COVID-19 begins in the UK and USA with an aim to reducing the severity of symptoms and avoiding hospitalization Of late, there...
Several studies indicate that activation of NLRP3 inflammasome is responsible for acute respiratory distress syndrome and/or acute lung injury (ARDS/ALI) seen in severely ill COVID-19 patients which often result in death due to multiple organ failure. This suggests NLRP3...
A combination of biological and computational approach to study protein-protein interactions (PPIs) between the viral and the host proteins in order to identify and repurpose drugs for an effective treatment of COVID-19 and possibly other infections as well The usual...
Development of vaccine for COVID-19 is a global priority. In this article, the author has reviewed and evaluated research and development and the present status of vaccine development. COVID-19 disease, caused by SARS-CoV-2 virus, has been steadily increasing in the...
Laboratory tests for diagnosis of COVID-19 currently in practice as advised by the international bodies of experts are reviewed and evaluated. The COVID-19 disease, that originated in Wuhan China, has affected more than 208 countries till now. The scientific community...
In a breakthrough research, the scientists have demonstrated that aminoglycosides (gentamicin) antibiotic could be used to treat familial dementia The antibiotics gentamicin, neomycin, streptomycin etc are commonly used to treat bacterial infections. These are broad spectrum antibiotics belonging to aminoglycosides...
The effects of partial gravity (example on Mars) on our muscular system is still partly understood. Study in rats shows that resveratrol, a compound found in grape skin and red wine, can mitigate muscle impairment in a Mars partial...
Early nerve transfer surgery to treat paralysis of arms and hands due to spinal injury is helpful in improving function. Post two years of surgery and physiotherapy, patients regained function in elbows and hands leading to improvement in independence...
Experiments in mice show that injecting amino-bridged nucleic acid-modified antisense oligonucleotides (amNA-ASO) into the brain is a potent and efficient approach to target SNCA protein for treatment of Parkinson’s disease More than 10 million people worldwide suffer from Parkinson’s disease...
Animal study describes role of URI protein in tissue regeneration after exposure to high-dose radiation from radiation therapy Radiation Therapy or Radiotherapy is an effective technique for killing cancer in the body and is majorly responsible for boosting cancer survival...
Study in mice and human cells describes reactivation of an important tumour suppressive gene using a vegetable extract thus offering a promising strategy for cancer treatment Cancer is the second leading cause of deaths worldwide. In cancer, multiple genetic and...
For the first time, delivery of genetic material induced heart cells to de-differentiate and proliferate in a large-animal model after myocardial infarction. This led to improvement in heart functions. According to WHO, around 25 million people worldwide are affected by...

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