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Attribution: NIH Image Gallery from Bethesda, Maryland, USA, Public domain, via Wikimedia Commons
A bill H.R.2316 - Fire Fauci Act1 has been introduced into the US Senate to reduce Dr. Anthony Fauci salary along with audit for his correspondence and financial statements linked to COVID-19 outbreak. During the initial days of COVID-19 outbreak, in March...
Europe is reeling with an unusually high number of COVID 19 cases for the past few weeks and this can be attributed to the highly transmissible delta variant along with relaxation in COVID norms with respect to wearing of...
Social interaction and vaccination both contribute to development of herd immunity however development of herd immunity as a result of social interaction is directly proportional to the number of secondary infections that arise from the primary cases. Herd immunity...
Medicines and Healthcare products Regulatory Agency (MHRA), the regulator of all medicines and medical devices in the UK has approved Moderna’s COVID-19 vaccine after meeting the required safety, quality and effectiveness standards for use in the UK (1).   This is the...
Herd immunity for COVID-19 is said to be achieved when 67% of the population is immune to the virus through infection and/or vaccination, whilst the pathogen remains well-characterized (unmutated) throughout transmission in the population that is well-characterized. In the...
Coronaviruses are RNA viruses belonging to coronaviridae family. These viruses display remarkably high rates of errors during replication due to lack of proofreading nuclease activity of their polymerases. In other organisms, the replication errors are corrected but the coronaviruses lack this ability. As...
COVID-19 situation across Europe and central Asia is very serious. According to WHO, Europe could face over 2 million COVID-19 deaths by March 2022. Wearing masks, physical distancing and vaccination are key preventive actions that could help avoid reaching this...
In order to raise levels of protection across the population against the Omicron variant, the Joint Committee on Vaccination and Immunisation (JCVI)1 of UK has recommended that the booster programme should be expanded to include all remaining adults aged 18...
MicroRNAs or in short miRNAs (not to be confused with mRNA or messenger RNA) were discovered in 1993 and have been extensively studied in the past two decades or so for their role in regulating gene expression. miRNAs are...
The government in England recently announced lifting of plan B measures amidst ongoing Covid-19 cases, that makes mask wearing not mandatory, dropping of work from home and no requirement by law of showing of COVID vaccination pass to attend...
Easily correctable condition of Vitamin D Insufficiency (VDI) has very severe implications for COVID-19. In countries worst affected by COVID-19 such as Italy, Spain and Greece, Vitamin D insufficiency (VDI) rates were high in the range of 70-90%.; on...
Coronaviruses and influenza viruses are sensitive to acidity of aerosol. pH-mediated rapid inactivation of coronaviruses is possible by enriching the indoor air with non-hazardous levels of nitric acid. Conversely, indoor air filter may unintentionally remove volatile acids thus prolonging...
The containment scheme based on 'quarantine' or 'social distancing' has emerged as the main tool in fight against COVID-19. But, there are concerns about economic and psychological costs. A researcher offers ''social containment'' as an alternative which seems to...
What causes severe COVID-19 symptoms? Evidences suggest inborn errors of type I Interferon immunity and autoantibodies against type I Interferon are causal for critical COVID-19. These errors can be identified using whole genome sequencing, thereby leading to proper quarantine...
Three adenoviruses used as vectors to produce COVID-19 vaccines, bind to platelet factor 4 (PF4), a protein implicated in the pathogenesis of clotting disorders.  Adenovirus based COVID-19 vaccines such as Oxford/AstraZeneca’s ChAdOx1 use the weakened and genetically modified version of common cold...
A plasmid DNA vaccine against SARS-CoV-2 has been found to induce immunity in animal trials. Few other DNA based vaccine candidates are at early stages of clinical trials. Interestingly, plasmid DNA vaccines can be developed in a short period of time....
A recent study suggests that single dose of Pfizer/BioNTech mRNA vaccine BNT162b2 provide protection against the new variants among individuals with prior infection.   The massive immunisation programme against the pandemic COVID-19 is currently underway. Simultaneously, there are reports of emergence of new variants...
Resistance to COVID-19 infection has been observed in health care workers and has been attributed to the presence of memory T cells that target the RNA polymerase in the RTC (replication transcription complex), thereby preventing infection. This makes RNA...
In the practice of medicine, one generally prefers time tested proven path while treating and trying to prevent diseases. An innovation is usually expected to pass the test of time. The three approved COVID-19 vaccines, two mRNA vaccines and...
COVID-19 pandemic has caused a major economic impact all over the globe and has resulted in disruption of “normal” life. Countries across the world are battling to find solutions to this disease that includes strengthening the immune system and...
Several new strains of the virus have emerged since the pandemic began. New variants were reported as early as February 2020. The current variant that has brought the UK to standstill this Christmas is said to be 70% more...
In countries like UK, USA and Italy which are badly hit by the COVID-19 pandemic, the life expectancy has reduced by at least 1.2-1.3 years. Diseases and risk factors lead to premature deaths and disabilities and result in ‘burden’ on the...
The recently completed UK-wide, ISARIC Study on analysis of 16749 patients with severe COVID-19 disease across 166 hospitals indicated that those with co-morbidity were at much higher risks while those with no significant comorbidity come out alive suggesting people...
Following assessment and approval by the European Medicines Agency (EMA), WHO has issued an emergency use listing (EUL) for Nuvaxovid on 21 December 2021. Earlier on 17 December 2021, the WHO had issued an emergency use listing (EUL) for Covovax.   Covovax and Nuvaxoid thus become the...
Sotrovimab, a Monoclonal antibody already approved for mild to moderate COVID-19 in several countries gets approval by MHRA in the UK. This antibody was intelligently designed with a mutating virus in mind. A highly conserved region of the spike protein was...

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