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COVID-19 pandemic has caused a major economic impact all over the globe and has resulted in disruption of “normal” life. Countries across the world are battling to find solutions to this disease that includes strengthening the immune system and...
In the practice of medicine, one generally prefers time tested proven path while treating and trying to prevent diseases. An innovation is usually expected to pass the test of time. The three approved COVID-19 vaccines, two mRNA vaccines and...
A plasmid DNA vaccine against SARS-CoV-2 has been found to induce immunity in animal trials. Few other DNA based vaccine candidates are at early stages of clinical trials. Interestingly, plasmid DNA vaccines can be developed in a short period of time....
Researchers at Southern Illinois University have reported a new variant of SARS COV-2 Virus in the USA.   According to reports published on preprint server which is yet to be peer-reviewed, researchers have identified a new variant using genomic virus surveillance approach.   Referred as 20C-US, this variant...
Medicines and Healthcare products Regulatory Agency (MHRA), the regulator of all medicines and medical devices in the UK has approved Moderna’s COVID-19 vaccine after meeting the required safety, quality and effectiveness standards for use in the UK (1).   This is the...
The preliminary report of findings from the clinical trial NCT02735707 reported in preprint suggests that Tocilizumab and Sarilumab, the interleukin-6 receptor antagonists are effective in treating critically ill COVID-19 patients and improve survival. Severely ill COVID-19 patients receiving intensive care support responded well to...
Controlling the rate of COVID-19 spread requires an accurate and a faster virus testing strategy. RT-PCR (reverse transcriptase polymerase chain reaction), the most accurate testing method being currently employed is a two-step test that takes around 60 minutes per sample.   The researchers from...
To protect the NHS and save lives., National Lockdown has been put in place across the UK. People have been asked to stay home at home. This is in view of recent rapid increase in number of cases across...
Interim data from the phase III clinical trial of Oxford University/AstraZeneca COVID-19 Vaccine show the vaccine is effective at preventing COVID-19 caused due to SARS-CoV-2 virus and offers a high level of protection against the disease.  The phase III trial tested two...
Viral proteins are administered as antigen in the form of a vaccine and the immune system of the body forms antibodies against the given antigen thus providing protection against any future infection. Interestingly, this is first time in human history...
What causes severe COVID-19 symptoms? Evidences suggest inborn errors of type I Interferon immunity and autoantibodies against type I Interferon are causal for critical COVID-19. These errors can be identified using whole genome sequencing, thereby leading to proper quarantine...
Anti-viral properties of manuka honey are due to the presence of methylglyoxal (MG), an arginine directed glycating agent that modifies sites specifically present in the SARS-CoV-2 genome, thereby interfering with its replication and inhibiting the virus. In addition, manuka...
University College London Hospitals (UCLH) has announced neutralising antibody trial against COVID-19. The announcement on 25 December 2020 says ‘’UCLH doses first patient in the world in Covid-19 antibody trial’’ and ‘’ Researchers in the STORM CHASER study led by...
Several new strains of the virus have emerged since the pandemic began. New variants were reported as early as February 2020. The current variant that has brought the UK to standstill this Christmas is said to be 70% more...
A novel mechanism to explain the different unrelated symptoms of COVID-19 has come to light by exploiting the second fastest Supercomputer in the world known as Summit supercomputer at Oak Ridge National Lab in Tennessee. The study involved analysing 2.5...
Existing biologics such as Canakinumab (monoclonal antibody), Anakinra (monoclonal antibody) and Rilonacept (fusion protein) can be exploited as therapeutics that restrain inflammation in COVID-19 patients. In addition, designer monoclonal antibodies can provide passive immunity by neutralizing the SARS-CoV-2 virus...
There are reports of Russia registering world’s first vaccine against novel corona virus while the phase 3 trial of this vaccine is still in progress. Developed jointly by the Gamaleya Research Institute and the Russian Defence Ministry, this vaccine is based on the use...
A type of virus that preys on bacteria could be harnessed to combat bacterial infections in patients whose immune systems have been weakened by the SARS-CoV-2 virus that causes the COVID-19 disease, according to an expert at the University...
Low-cost dexamethasone reduces death by up to one third in hospitalised patients with severe respiratory complications of COVID-19 The scientists have been sceptic over the rationale for prolonged corticosteroid treatment in the Acute Respiratory Distress Syndrome (ARDS) caused by COVID-19....
Easily correctable condition of Vitamin D Insufficiency (VDI) has very severe implications for COVID-19. In countries worst affected by COVID-19 such as Italy, Spain and Greece, Vitamin D insufficiency (VDI) rates were high in the range of 70-90%.; on...
A biotech firm, Moderna, Inc. has announced that ‘mRNA-1273’, their mRNA vaccine against novel coronavirus has shown positive results in the phase 1 clinical trials In the race for the development of vaccines for the treatment of COVID-19, Moderna Inc.,...
Clinical Trials to evaluate effectiveness of anti-malarial drug, hydroxychloroquine (HCQ) and antibiotic, Azithromycin in treating older people with COVID-19 begins in the UK and USA with an aim to reducing the severity of symptoms and avoiding hospitalization Of late, there...
Several studies indicate that activation of NLRP3 inflammasome is responsible for acute respiratory distress syndrome and/or acute lung injury (ARDS/ALI) seen in severely ill COVID-19 patients which often result in death due to multiple organ failure. This suggests NLRP3...
Humans would not have existed without viruses because viral protein plays a key role in the development of human embryo. However, at times, they pose existential threats in the form of diseases as in the case of current COVID-19...
A combination of biological and computational approach to study protein-protein interactions (PPIs) between the viral and the host proteins in order to identify and repurpose drugs for an effective treatment of COVID-19 and possibly other infections as well The usual...

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