Story of Coronaviruses: How the ‘’novel Coronavirus (SARS-CoV-2)’’ May Have Emerged?

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Coronaviruses are not new; these are as old as anything in the world and are known to cause common cold among humans for ages. However, its latest variant, the ‘SARS-CoV-2’ currently in news for causing COVID-19 pandemic is new.  

Coronavirus

Often, common cold (caused by coronavirus and other viruses such as rhinoviruses) is confused with flu.   

Flu and common cold, though both present similar symptoms are different in the sense that they are caused by different viruses altogether.  

Flu or influenza viruses have a segmented genome which cause antigenic shift which occurs due to recombination among viruses of the same genus, thus changing the nature of the proteins on the viral surface responsible for generating immune response. This is further complicated by a phenomenon called antigenic drift which results from virus accumulating mutations (change in its DNA structure) over a period of time that causes changes in the nature of surface proteins. All this makes it difficult to develop vaccine against them that could provide protection for long duration.  The last pandemic of Spanish Flu of 1918 that killed millions of people was caused by flu or influenza virus. This is different from the coronaviruses.  

Coronaviruses, responsible for causing Common cold, on the other hand, do not possess a segmented genome hence there is no antigenic shift. They were minimally virulent and occasionally lead to death of the affected people. The virulence of coronaviruses is normally limited to cold symptoms only and rarely made anyone seriously sick. However, there were some virulent forms of coronaviruses in the recent past, namely SARS (Severe Acute Respiratory Syndrome) that appeared in 2002-03 in Southern China and caused 8096 cases, resulting in 774 deaths in 26 countries and MERS (Middle East Respiratory Syndrome) that appeared 9 years later in 2012 in Saudi Arabia and caused 2494 cases, resulting in 858 deaths in 27 countries1. However, this remained endemic and disappeared relatively quickly (within 4-6 months), possibly due to its less virulent nature and/or by following proper epidemiological procedures for containment. Hence, no need was felt at that time to invest heavily and develop a vaccine against such a coronavirus.  

The latest variant of coronavirus, the novel coronavirus (SARS-CoV-2) seems to be related to SARS and MERS2 which is highly infectious and virulent in humans. It was identified first in Wuhan China but soon became an epidemic and spread across the world to take the form of pandemic. Was this rapid spread across select geographies solely due to the high virulence and infectivity caused by changes in the genetic constitution of the virus or possibly due to lack of timely epidemiological intervention by reporting to the concerned national/transnational authorities which prevented timely containment measures, thereby causing about a million deaths so far and bringing the world economy to the grinding halt.    

This is the first time in the human history that the existing coronavirus reportedly underwent changes in its genome that made it into a highly virulent variant, responsible for the current pandemic.  

But what may have caused such a drastic antigenic drift making the SARS-CoV-2 so virulent and infectious?  

There are several theories going around in the scientific community pointing to the origin of SARS-CoV-23,4. Proponents of man-made origin of the virus believe that the genome changes seen in SARS-CoV-2 would take am extremely long period of time to develop naturally, while other studies argue that it may be of natural origin5 because if humans were to create the virus artificially, why would they create a sub-optimal form that is virulent enough to cause a severe disease but binds sub-optimally to the human cells and the fact that it was not created using the backbone of the known virus. 

Be as it may, the fact of the matter remains that a certain almost innocuous virus underwent genetic changes to transform itself to become mildly virulent SARS/MERS, and finally into a highly infectious and virulent form (SARS-CoV-2) in a span of 18-20 years, appears unusual. Such drastic antigenic drift, which incidentally has a continuum in between, would be highly unlikely to happen in a normal course, in the laboratory of Mother Earth, in such a short time duration. Even if it were to be true, what’s more perplexing is the environmental pressure that would have triggered such a selection in the evolution?  

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References: 

  1. Padron-Regalado E. Vaccines for SARS-CoV-2: Lessons from Other Coronavirus Strains [published online ahead of print, 2020 Apr 23]. Infect Dis Ther. 2020;9(2):1-20. doi: https://doi.org/10.1007/s40121-020-00300-x    
  1. Liangsheng Z, Fu-ming S, Fei C, Zhenguo L. Origin and Evolution of the 2019 Novel Coronavirus, Clinical Infectious Diseases, Volume 71, Issue 15, 1 August 2020, Pages 882–883, DOI:https://doi.org/.1093/cid/ciaa112 
  1. Morens DM, Breman JG, et al 2020. The Origin of COVID-19 and Why It Matters. The American Society of Tropical Medicine and Hygiene. Available online: 22 July 2020. DOI: https://doi.org/10.4269/ajtmh.20-0849  
  1. York A. Novel coronavirus takes flight from bats? Nat Rev Microbiol 18, 191 (2020). DOI:https://doi.org/10.1038/s41579-020-0336-9  
  1. Andersen KG, Rambaut, A., Lipkin, W.I. et al. The proximal origin of SARS-CoV-2. Nat Med 26, 450–452 (2020). DOI: https://doi.org/10.1038/s41591-020-0820-9

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