Study shows a new combination therapy of two plant-derived compounds to reverse cognitive impairment in mice
At least 50 million people are living with Alzheimer’s disease worldwide. The total number of patients of Alzheimer’s disease could exceed 152 million by...
Experiments in mice show that injecting amino-bridged nucleic acid-modified antisense oligonucleotides (amNA-ASO) into the brain is a potent and efficient approach to target SNCA protein for treatment of Parkinson’s disease
More than 10 million people worldwide suffer from Parkinson’s disease...
New study shows a second case of successful HIV remission after a bone marrow transplant
At least one million people die due to HIV-related causes every year and almost 35 million are living with HIV. HIV-1 (Human Immunodeficiency Virus) is...
A new pill has been designed which delivers insulin into the bloodstream easily and pain-free, in pigs for now
Insulin is an important hormone required to break down the blood sugar – glucose - to prevent further illnesses. Since sugar...
Selegiline is an irreversible monoamine oxidase (MAO) B inhibitor1. Monoamine neurotransmitters, such as serotonin, dopamine and norepinephrine, are derivatives of amino acids2. The enzyme monoamine oxidase A (MAO A) primarily oxidises (breaks down) serotonin and norepinephrine in the brain,...
Donepezil is an acetylcholinesterase inhibitor1. Acetylcholinesterase breaks down the neurotransmitter acetylcholine2, thereby reducing acetylcholine signalling in the brain. Acetylcholine (ACh) enhances the encoding of new memories and therefore improves learning3. Donepezil improves cognitive performance in mild cognitive impairment (MCI)...
Tildrakizumab is being marketed by Sun Pharma under the trade name Ilumya, and has been approved by FDA in March 2018 after analysis of data from Phase III multi-centre, randomised, placebo-controlled clinical trials reSURFACE 1 and reSURFACE 2. Both...
In a breakthrough research, the scientists have demonstrated that aminoglycosides (gentamicin) antibiotic could be used to treat familial dementia
The antibiotics gentamicin, neomycin, streptomycin etc are commonly used to treat bacterial infections. These are broad spectrum antibiotics belonging to aminoglycosides...
Study in mice and human cells describes reactivation of an important tumour suppressive gene using a vegetable extract thus offering a promising strategy for cancer treatment
Cancer is the second leading cause of deaths worldwide. In cancer, multiple genetic and...
Developing vaccine against malaria has been among the biggest challenges before science. MosquirixTM , a vaccine against malaria has recently been approved by WHO. Although the efficacy of this vaccine is about 37%, yet this is great step forward as this...
Development of multi-drug resistance (MDR) bacteria in the past five decades have led to increasing research in search of a drug candidate to address this AMR issue. A fully synthetic broad-spectrum antibiotic, Iboxamycin, provides hope to treat both Gram-positive and Gram-negative bacteria...
Self-assembled nanostructures formed using supramolecular polymers containing peptide amphiphiles (PAs) containing bio active sequences have shown great results in mouse model of SCI and holds immense promise, in humans, for an effective treatment of this debilitating condition that severely impacts the quality of life...
RNA technology has proved its worth recently in development of mRNA vaccines BNT162b2 (of Pfizer/BioNTech) and mRNA-1273 (of Moderna) against COVID-19. Based on degrading the coding RNA in animal model, French scientists have reported a potent strategy and proof of...
Doctors and scientists of University of Maryland School of Medicine have successfully transplanted heart of a genetically engineered pig (GEP) into an adult patient with end-stage heart disease. This surgery was patient’s only option left for survival after being...
Successful development of mRNA vaccines, BNT162b2 (of Pfizer/BioNTech) and mRNA-1273 (of Moderna) against the novel coronavirus SARS CoV-2 and the important role these vaccines played recently in mass immunisation of people against COVID-19 pandemic in several countries has established...
Monkeypox virus (MPXV) is closely related to smallpox, the deadliest virus in history responsible for unparalleled devastation of human population in the past centuries accounting for more deaths than any other single infectious disease, even plague and cholera. With...
Two henipaviruses, Hendra virus (HeV) and the Nipah virus (NiV) are already known to cause fatal disease in humans. Now, a novel henipavirus has been identified in febrile patients in Eastern China. This is phylogenetically distinct strain of henipavirus...
On 08 August 2022, the expert group of WHO arrived at consensus on nomenclature of known and new monkeypox virus (MPXV) variants or clades. Accordingly, the former Congo Basin (Central African) clade will be known as Clade one(I) and...
Using appropriate enzymes, researchers removed ABO blood group antigens from donor kidney and lung ex-vivo, to overcome ABO blood group mismatch. This approach can solve organ shortage by improving availability of donor organs for transplantation considerably and make the...
In a recent in-vivo study on Zebrafish, researchers successfully induced disc regeneration in a degenerated disc by activating an endogenous Ccn2a-FGFR1-SHH signalling cascade. This suggests that Ccn2a protein could be exploited in promotion of IVD regeneration for treatment of backpain.
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Brain-eating Amoeba (Naegleria fowleri) is responsible for brain infection known as primary amoebic meningoencephalitis (PAM). The infection rate is very low but highly fatal. The infection is contacted through taking up water contaminated with N. fowleri through nose. Antibiotics...
Researchers have found that memory in aged monkey improved following a single administration of low-dose Klotho protein. It is the first time that restoring levels of klotho has been shown to improve cognition in a non-human primate. This paves the...
This year’s Nobel Prize in Physiology or Medicine 2023 has been awarded jointly to Katalin Karikó and Drew Weissman "for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19".
Both Katalin Karikó and...
A new vaccine, R21/Matrix-M has been recommended by the WHO for the prevention of malaria in children.
Earlier in 2021, WHO had recommended RTS,S/AS01 malaria vaccine for prevention of malaria in children. This was the first malaria vaccine to...
Antibiotic resistance particularly by Gram-negative bacteria has nearly created a crisis like situation. The novel antibiotic Zosurabalpin (RG6006) shows promises. It has been found to be effective against drug-resistant, Gram-negative bacteria CRAB in pre-clinical studies.
Antimicrobial resistance (AMR), driven mainly by...
