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The technology used by Cuba to develop protein-based vaccines against COVID-19 can lead to development of vaccines against new mutated strains in a relatively easier manner. World’s first protein conjugate vaccines have been developed by exploiting the RBD (receptor binding...
Following assessment and approval by the European Medicines Agency (EMA), WHO has issued an emergency use listing (EUL) for Nuvaxovid on 21 December 2021. Earlier on 17 December 2021, the WHO had issued an emergency use listing (EUL) for Covovax.   Covovax and Nuvaxoid thus become the...
Sotrovimab, a Monoclonal antibody already approved for mild to moderate COVID-19 in several countries gets approval by MHRA in the UK. This antibody was intelligently designed with a mutating virus in mind. A highly conserved region of the spike protein was...
A new variant called ‘IHU’ (a new Pangolin lineage named B.1.640.2) is reported to have emerged in south-eastern France.   Researchers in Marseille, France have reported detection of a new variant of novel coronavirus SARS-CoV-2.   The index patient had recent travel history...
Effective 27th January 2022, it will not be mandatory to wear a face covering or need to show COVID pass in England. The measures put in place under Plan B in England, to be lifted.   Earlier on 8th December...
The government in England recently announced lifting of plan B measures amidst ongoing Covid-19 cases, that makes mask wearing not mandatory, dropping of work from home and no requirement by law of showing of COVID vaccination pass to attend...
Three adenoviruses used as vectors to produce COVID-19 vaccines, bind to platelet factor 4 (PF4), a protein implicated in the pathogenesis of clotting disorders.  Adenovirus based COVID-19 vaccines such as Oxford/AstraZeneca’s ChAdOx1 use the weakened and genetically modified version of common cold...
A gene variant of OAS1 has been implicated in reducing the risk of severe COVID-19 disease. This warrants developing agents/drugs that can increase the level of OAS1 enzyme, thereby reducing the severity of COVID-19. Advanced age and comorbidities are known...
Fluvoxamine is an inexpensive anti-depressant commonly used in mental healthcare. Evidence from the recently concluded clinical trial suggest that it can be repurposed to treat patients with COVID-19. It is found to reduce risk of severe COVID-19 symptoms, reduces need...
The eighth version (seventh update) of a living guideline is released. It replaces earlier versions. The latest update includes a strong recommendation for the use of baricitinib as an alternative to interleukin-6 (IL-6), a conditional recommendation for the use of...
Omicron BA.2 subvariant seems to be more transmissible than BA.1. It also possesses immune-evasive properties that further reduce the protective effect of vaccination against infection.  On 26 November 2021, WHO had designated B.1.1.529 variant of SARS-CoV-2 as a Variant of...
Coronaviruses and influenza viruses are sensitive to acidity of aerosol. pH-mediated rapid inactivation of coronaviruses is possible by enriching the indoor air with non-hazardous levels of nitric acid. Conversely, indoor air filter may unintentionally remove volatile acids thus prolonging...
WHO has updated its living guidelines on COVID-19 therapeutics. The ninth update released on 03 March 2022 include a conditional recommendation on molnupiravir.  Molnupiravir has become the first oral antiviral drug to be included in the treatment guidelines for COVID-19....
Cases of co-infections with two variants were earlier reported. Not much was known about viral recombination yielding viruses with hybrid genomes. Two recent studies report cases of genetic recombination among SARS-CoV-2 variants Denta & Omicron. The recombinant, called Deltamicron, had...

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